Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target
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چکیده
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Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target
Dysregulation of eating behavior can lead to obesity, which affects 10% of the adult population worldwide and accounts for nearly 3 million deaths every year. Despite this burden on society, we currently lack effective pharmacological treatment options to regulate appetite. We used Drosophila melanogaster larvae to develop a high-throughput whole organism screen for drugs that modulate food int...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2013
ISSN: 2045-2322
DOI: 10.1038/srep02120